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Title: Myf6  
Author: World Heritage Encyclopedia
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Subject: PITX2, Myogenesis, Human genes, NeuroD, EMX homeogene
Publisher: World Heritage Encyclopedia


Myogenic factor 6 (herculin)
Symbols  ; CNM3; MRF4; bHLHc4; myf-6
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Myogenic factor 6 (herculin) is a protein that in humans is encoded by the MYF6 gene. [1] Also known in the medical literature as MRF4 and herculin), MYF6 is a myogenic regulatory factor (MRF) in the process known as myogenesis.[2][3]


MYF6 is a member of the myogenic factors (MYF) family that regulate myogenesis and muscle regeneration. Myogenic factor are basic helix-loop-helix (bHLH) transcription factors. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM).

Clinical significance

Mutations in the MYF6 gene are associated with myopathy.[4]


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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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