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Hoxa11

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Title: Hoxa11  
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Hoxa11

Homeobox A11
Identifiers
Symbols  ; HOX1; HOX1I
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.[1][2][3] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.[3]

See also

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3.  
  3. ^ a b "Entrez Gene: HOXA11 homeobox A11". 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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